Endocrine Abstracts

FGF23 is a phosphotropic hormone produced by bone. FGF23 23 reduces serum phosphate by suppressing proximal tubular phosphate reabsorption and intestinal phosphate absorption. Since the identification of FGF23 in 2000, several hypophosphatemic diseases such as X-linked hypophosphatemic rickets (XLH) and tumor-induced osteomalacia (TIO) have been shown to be caused by excessive actions of FGF23. TIO is a paraneoplastic disease and can be cured by complete removal of responsible...